PhytophthoraEffectorV1, Main, Exploration, bibRecord, 000177

An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

Identifieur interne : 000177 ( Main/Exploration ); précédent : 000176; suivant : 000178

An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

Auteurs : Tianqiao Song [République populaire de Chine] ; Zhenchuan Ma [République populaire de Chine] ; Danyu Shen [République populaire de Chine] ; Qi Li [République populaire de Chine] ; Wanlin Li [République populaire de Chine] ; Liming Su [République populaire de Chine] ; Tingyue Ye [République populaire de Chine] ; Meixiang Zhang [République populaire de Chine] ; Yuanchao Wang [République populaire de Chine] ; Daolong Dou [République populaire de Chine]

Source :

PLoS pathogens [ 1553-7374 ] ; 2015.

RBID : pubmed:26714171

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Blotting, Western (MeSH), Chromatin Immunoprecipitation (MeSH), DNA-Binding Proteins (genetics), Electrophoretic Mobility Shift Assay (MeSH), Genes, Plant (genetics), Genes, Plant (immunology), Heat Shock Transcription Factors (MeSH), Heat-Shock Proteins (genetics), Host-Parasite Interactions (immunology), Microscopy, Fluorescence (MeSH), Molecular Sequence Data (MeSH), Phytophthora (immunology), Phytophthora (pathogenicity), Plant Diseases (genetics), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Proteins (genetics), Plants, Genetically Modified (MeSH), Real-Time Polymerase Chain Reaction (MeSH), Transcription Factors (genetics), Virulence Factors (immunology).
MESH :
- chemical , genetics : DNA-Binding Proteins, Heat-Shock Proteins, Plant Proteins, Transcription Factors.
- genetics : Genes, Plant, Plant Diseases.
- immunology : Genes, Plant, Host-Parasite Interactions, Phytophthora, Plant Diseases, Virulence Factors.
- microbiology : Plant Diseases.
- pathogenicity : Phytophthora.
- Amino Acid Sequence, Blotting, Western, Chromatin Immunoprecipitation, Electrophoretic Mobility Shift Assay, Heat Shock Transcription Factors, Microscopy, Fluorescence, Molecular Sequence Data, Plants, Genetically Modified, Real-Time Polymerase Chain Reaction.

Abstract

Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.

DOI: 10.1371/journal.ppat.1005348
PubMed: 26714171
PubMed Central: PMC4695088

Affiliations:

République populaire de Chine

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Blotting, Western (MeSH)</term>
<term>Chromatin Immunoprecipitation (MeSH)</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>Electrophoretic Mobility Shift Assay (MeSH)</term>
<term>Genes, Plant (genetics)</term>
<term>Genes, Plant (immunology)</term>
<term>Heat Shock Transcription Factors (MeSH)</term>
<term>Heat-Shock Proteins (genetics)</term>
<term>Host-Parasite Interactions (immunology)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Phytophthora (immunology)</term>
<term>Phytophthora (pathogenicity)</term>
<term>Plant Diseases (genetics)</term>
<term>Plant Diseases (immunology)</term>
<term>Plant Diseases (microbiology)</term>
<term>Plant Proteins (genetics)</term>
<term>Plants, Genetically Modified (MeSH)</term>
<term>Real-Time Polymerase Chain Reaction (MeSH)</term>
<term>Transcription Factors (genetics)</term>
<term>Virulence Factors (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Données de séquences moléculaires (MeSH)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de virulence (immunologie)</term>
<term>Gènes de plante (génétique)</term>
<term>Gènes de plante (immunologie)</term>
<term>Immunoprécipitation de la chromatine (MeSH)</term>
<term>Interactions hôte-parasite (immunologie)</term>
<term>Maladies des plantes (génétique)</term>
<term>Maladies des plantes (immunologie)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Phytophthora (immunologie)</term>
<term>Phytophthora (pathogénicité)</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Protéines du choc thermique (génétique)</term>
<term>Protéines végétales (génétique)</term>
<term>Réaction de polymérisation en chaine en temps réel (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Technique de Western (MeSH)</term>
<term>Test de retard de migration électrophorétique (MeSH)</term>
<term>Végétaux génétiquement modifiés (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>Heat-Shock Proteins</term>
<term>Plant Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, Plant</term>
<term>Plant Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Gènes de plante</term>
<term>Maladies des plantes</term>
<term>Protéines de liaison à l'ADN</term>
<term>Protéines du choc thermique</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Gènes de plante</term>
<term>Interactions hôte-parasite</term>
<term>Maladies des plantes</term>
<term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Genes, Plant</term>
<term>Host-Parasite Interactions</term>
<term>Phytophthora</term>
<term>Plant Diseases</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Blotting, Western</term>
<term>Chromatin Immunoprecipitation</term>
<term>Electrophoretic Mobility Shift Assay</term>
<term>Heat Shock Transcription Factors</term>
<term>Microscopy, Fluorescence</term>
<term>Molecular Sequence Data</term>
<term>Plants, Genetically Modified</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term>
<term>Immunoprécipitation de la chromatine</term>
<term>Microscopie de fluorescence</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Séquence d'acides aminés</term>
<term>Technique de Western</term>
<term>Test de retard de migration électrophorétique</term>
<term>Végétaux génétiquement modifiés</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters. </div>
</front>
</TEI>
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<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>02</Month>
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<Title>PLoS pathogens</Title>
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<ArticleTitle>An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.</ArticleTitle>
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<Abstract><AbstractText>Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Tianqiao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Zhenchuan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shen</LastName>
<ForeName>Danyu</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Qi</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wanlin</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Su</LastName>
<ForeName>Liming</ForeName>
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   |texte=   An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.
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	Serveur d'exploration sur les effecteurs du phytophthora
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Serveur d'exploration sur les effecteurs du phytophthora

An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.

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